Epidemiological and experimental evidence implicates oestrogens in the aetiology of breast cancer.
to cancer breast linked Estrogen
Clinical and experimental data also suggest the possibility that receptor independent effects of E 2 may be mechanistically involved. They might induce direct and indirect free-radical-mediated DNA damage, genetic instability, and mutations in cells in culture and in vivo [ 77 ]. Several recent epidemiological studies have observed an association between risk for breast cancer and polymorphisms in genes involved in oestrogen synthesis, such as CYP17 and CYP19 , and in HSD17B1 , which codes for an enzyme that converts oestrone to oestradiol [ 40 , 41 ].
Also, they want to use more advanced tests that have become available, and measure more types of estrogen byproducts. Introduction Epidemiological and experimental evidence implicates oestrogens in the aetiology of breast cancer. ScienceDaily shares links with scholarly publications in the TrendMD network and earns revenue from third-party advertisers, where indicated.